Journal of Pharmacology and Therapeutics ISSN(2836-5364)
Recent Articles
Microbial Enzyme As Therapeutical Approach For The Disease’s Targets
Microorganisms produces wide variety of biomolecules, these need to detect and used for specific application. The extremophilic microorganisms have lots of potential to assay the activity as per desired requirement as per applied used..
View ArticleRebalance Of Mitophagy By Inhibiting LRRK2 Improves Parkinson’s Disease-Related Colon Dysfunctions
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common genetic causes of Parkinson’s disease (PD). Pathogenic mutations of LRRK2 cause increased autophosphorylation as well as Rab substrate GTPase phosphorylation which are associated with dopaminergic neuron death, impaired neurotransmission, and inflammatory response. Early preclinical studies suggested a protective role of LRRK2 inhibitors in PD patients and in in vivo models.
View ArticleImatinib Maternal Use: A Case Report
To report a case of condom use alongside imatinib use in a vasectomized patient. A 45-year-old premenopausal woman sought counsel from the Medicine Pregnancy and Lactation Policlinic of the Isala Clinics (MAZ, Zwolle, and The Netherlands) in September 2020 regarding the medication her spouse was taking.
View ArticleCabozantinib Adverse Reactions In Patients With Renal Cell Carcinoma
The most recent first-line therapy for Metastatic Renal Cell Carcinoma (mRCC) is Cabozantinib (CAB), a Tyrosine Kinase Inhibitor (TKI). Skin responses in a patient with RCC are among the reports of adverse CAB reactions. Other TKI (Sunitinib) reported cases of acute interstitial nephritis caused by medication.
View ArticleAiming To Make A New Nano-Formula To Regulate The Binding Of Recombinant Human Growth Hormone
Because most biomolecules are unstable when they are being adsorbed on a hydrophobic polymer, the polymer surface can be altered to accommodate the way that proteins bind to it. Specific interaction domains that need substrate specificity are involved in the binding of a protein to a biomolecule. Protein-binding epitopes can be produced by isolating these interaction regions and integrating them into lengthy polypeptide chains.
View ArticleUsing Glucose Contransporter-2 Inhibitors (SGLT2-I) As An Add-On To Metforrmin
Non-severe hypoglycemia impairs quality of life, productivity, and well-being while also raising treatment expenses. The non-severe hypoglycemia rate associated with the use of sulfonylureas (SU) in comparison to newer classes like SGLT2-I may be clinically significant.
View ArticleSARS-CoV-2 : Accumulation Of Mutations With Time Decreases The Infectivity And Virulence Of RNA Viruses
The probability of evolving increases with the rate of mutation, and the possibility of extinction increases with the rate of evolution. According to my hypothesis, pharmacologically accelerating the rate of mutations in the viral progeny genomes would aid in the eradication of the virus’ virulence...
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