Insight Journal of Oral and Maxillofacial Surgery
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Supramolecular Complexes Of Etacizine With Glycosides As Promising New Antiarrhythmic Drugs
The problem of effective and safe therapy of cardiac arrhythmias requires the creation of new antiarrhythmic drugs with low toxicity. Clathration of medicinal substances with cyclodextrins or plant glycosides is a promising method for reducing their side effects and increasing their solubility. Complexes of glycyrrhizic acid (GA) and its monoammonium salt (MASGA) with ethacizine hydrochloride (EtHC) in various molar ratios (2:1, 4:1, 8:1) characterized by certain physicochemical parameters have been obtained.
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